Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma

The under-regulation of liver-specific MAT1A gene codifying for S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and the up-regulation of widely expressed MAT2A, MATII isozyme occurs in hepatocellular carcinoma (HCC). MATα1:MATα2 switch strongly contributes to the fall in SAM liver content...

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Bibliographic Details
Published in:Transl Gastroenterol Hepatol
Main Authors: Pascale, Rosa M., Feo, Claudio F., Calvisi, Diego F., Feo, Francesco
Format: Artigo
Language:Inglês
Published: AME Publishing Company 2018
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044036/
https://ncbi.nlm.nih.gov/pubmed/30050996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tgh.2018.06.04
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