Serum neurofilament light chain is increased in hereditary spastic paraplegias

Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared...

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Bibliographic Details
Published in:Ann Clin Transl Neurol
Main Authors: Wilke, Carlo, Rattay, Tim W., Hengel, Holger, Zimmermann, Milan, Brockmann, Kathrin, Schöls, Ludger, Kuhle, Jens, Schüle, Rebecca, Synofzik, Matthis
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043776/
https://ncbi.nlm.nih.gov/pubmed/30009206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.583
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