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Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a ‘‘molecular mop” in immune response ()

Serum amyloid A (SAA) is an acute-phase protein whose action in innate immunity and lipid homeostasis is unclear. Most circulating SAA binds plasma high-density lipoproteins (HDL) and reroutes lipid transport. In vivo SAA binds existing lipoproteins or generates them de novo upon lipid uptake from c...

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Vydáno v:J Struct Biol
Hlavní autoři: Frame, Nicholas M., Jayaraman, Shobini, Gantz, Donald L., Gursky, Olga
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042646/
https://ncbi.nlm.nih.gov/pubmed/28645735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2017.06.007
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