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Cancer-mutation network and the number and specificity of driver mutations

Cancer genomics has produced extensive information on cancer-associated genes, but the number and specificity of cancer-driver mutations remains a matter of debate. We constructed a bipartite network in which 7,665 tumors from 30 cancer types are connected via shared mutations in 198 previously iden...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Iranzo, Jaime, Martincorena, Iñigo, Koonin, Eugene V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042135/
https://ncbi.nlm.nih.gov/pubmed/29895694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803155115
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