A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

The intravascular processing of triglyceride-rich lipoproteins depends on lipoprotein lipase (LPL) and GPIHBP1, a membrane protein of endothelial cells that binds LPL within the subendothelial spaces and shuttles it to the capillary lumen. In the absence of GPIHBP1, LPL remains mislocalized within t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kristensen, Kristian K., Midtgaard, Søren Roi, Mysling, Simon, Kovrov, Oleg, Hansen, Lars Bo, Skar-Gislinge, Nicholas, Beigneux, Anne P., Kragelund, Birthe B., Olivecrona, Gunilla, Young, Stephen G., Jørgensen, Thomas J. D., Fong, Loren G., Ploug, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042107/
https://ncbi.nlm.nih.gov/pubmed/29899144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806774115
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