Ruxolitinib - a Steroid Sparing Agent in Chronic Graft-versus-Host Disease

Inhibition of the Janus-associated kinases (JAK) with ruxolitinib (RUX) reduces graft-versus-host disease (GVHD) in preclinical and clinical models. Nineteen allograft recipients with moderate/severe steroid-dependent chronic GVHD received RUX as ≥ 2nd line salvage. RUX was well tolerated, and led t...

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Dettagli Bibliografici
Pubblicato in:Bone Marrow Transplant
Autori principali: Khoury, Hanna Jean, Langston, Amelia A., Kota, Vamsi K., Wilkinson, Jennifer A., Pusic, Iskra, Jillella, Anand, Bauer, Stephanie, Kim, Audrey S, Roberts, Danielle, Al-Kadhimi, Zaid, Bodo, Imre, Winton, Elliott, Arellano, Martha, DiPersio, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041160/
https://ncbi.nlm.nih.gov/pubmed/29367708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41409-017-0081-5
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