BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance

Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. More than 90% of patients with SSc are positive for autoantibodies. In addition, serum B cell activating factor (BAFF) level is correlated with SSc severity and activity. Thus, B cells are considered to play a...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Matsushita, Takashi, Kobayashi, Tadahiro, Mizumaki, Kie, Kano, Miyu, Sawada, Tomoyo, Tennichi, Momoko, Okamura, Ai, Hamaguchi, Yasuhito, Iwakura, Yoichiro, Hasegawa, Minoru, Fujimoto, Manabu, Takehara, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040844/
https://ncbi.nlm.nih.gov/pubmed/30009261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aas9944
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