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Establishment of environmentally sensitive DNA methylation states in the very early human embryo

The molecular mechanisms responsible for the developmental origins of later disease are currently unknown. We previously demonstrated that women’s periconceptional nutrition predicts their offspring’s DNA methylation at metastable epialleles (MEs). We present a genome-wide screen yielding 687 MEs an...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Kessler, Noah J., Waterland, Robert A., Prentice, Andrew M., Silver, Matt J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040841/
https://ncbi.nlm.nih.gov/pubmed/30009262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat2624
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