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Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon–Metal Bond Cleavage

The organomercurial lyase MerB has the unique ability to cleave carbon–Hg bonds, and structural studies indicate that three residues in the active site (C96, D99, and C159 in E. coli MerB) play important roles in the carbon–Hg bond cleavage. However, the role of each residue in carbon–metal bond cle...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Wahba, Haytham M., Stevenson, Michael J., Mansour, Ahmed, Sygusch, Jurgen, Wilcox, Dean E., Omichinski, James G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040655/
https://ncbi.nlm.nih.gov/pubmed/27989130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11327
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