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CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1

Growing evidence demonstrates that the highly conserved serine/threonine kinase CK2 promotes Th17 cell differentiation while suppressing the generation of Foxp3(+) Tregs; however, the exact mechanism by which CK2 regulates the Th17/Treg axis remains unclear. CK2 can be comprised of 3 distinct subuni...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Gibson, Sara A., Yang, Wei, Yan, Zhaoqi, Qin, Hongwei, Benveniste, Etty N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040220/
https://ncbi.nlm.nih.gov/pubmed/29891553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701592
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