Recent advances in heart transplantation

Despite advances in medical and electrical therapies for heart failure, morbidity and mortality remain high and patients often progress to end-stage heart failure. Over the last five decades, heart transplantation is considered a standard therapy for select patients with end-stage heart failure. How...

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Publicado no:F1000Res
Autor principal: Kittleson, Michelle M
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2018
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039932/
https://ncbi.nlm.nih.gov/pubmed/30026915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.14737.1
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spelling pubmed-60399322018-07-18 Recent advances in heart transplantation Kittleson, Michelle M F1000Res Review Despite advances in medical and electrical therapies for heart failure, morbidity and mortality remain high and patients often progress to end-stage heart failure. Over the last five decades, heart transplantation is considered a standard therapy for select patients with end-stage heart failure. However, while heart transplantation has become a treatment of choice for end-stage heart failure, challenges still exist for improvement in the short- and long-term outcomes. While there is an increase in the number of patients with end-stage heart failure, the number of donor organs remains a major limiting factor. Heart transplantation candidates in the current era are also more complex: older, antigen-sensitized, and on mechanical circulatory support at the time of listing and transplant. Such potential heart transplant recipients have an increased chance of problems, including antibody-mediated rejection and primary graft dysfunction. Recent advances could address the current challenges and include: 1) attempts to expand the pool of donor hearts; 2) changes in heart transplantation allocation policy allowing for more equitable organ distribution; and 3) advances in the management of antibody sensitization. Developments in these areas could result in improved survival and quality of life for heart transplantation recipients. F1000 Research Limited 2018-07-05 /pmc/articles/PMC6039932/ /pubmed/30026915 http://dx.doi.org/10.12688/f1000research.14737.1 Text en Copyright: © 2018 Kittleson MM http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Review
spellingShingle Review
Kittleson, Michelle M
Recent advances in heart transplantation
description Despite advances in medical and electrical therapies for heart failure, morbidity and mortality remain high and patients often progress to end-stage heart failure. Over the last five decades, heart transplantation is considered a standard therapy for select patients with end-stage heart failure. However, while heart transplantation has become a treatment of choice for end-stage heart failure, challenges still exist for improvement in the short- and long-term outcomes. While there is an increase in the number of patients with end-stage heart failure, the number of donor organs remains a major limiting factor. Heart transplantation candidates in the current era are also more complex: older, antigen-sensitized, and on mechanical circulatory support at the time of listing and transplant. Such potential heart transplant recipients have an increased chance of problems, including antibody-mediated rejection and primary graft dysfunction. Recent advances could address the current challenges and include: 1) attempts to expand the pool of donor hearts; 2) changes in heart transplantation allocation policy allowing for more equitable organ distribution; and 3) advances in the management of antibody sensitization. Developments in these areas could result in improved survival and quality of life for heart transplantation recipients.
author Kittleson, Michelle M
author_facet Kittleson, Michelle M
author_sort Kittleson, Michelle M
title Recent advances in heart transplantation
title_short Recent advances in heart transplantation
title_full Recent advances in heart transplantation
title_fullStr Recent advances in heart transplantation
title_full_unstemmed Recent advances in heart transplantation
title_sort recent advances in heart transplantation
publisher F1000 Research Limited
container_title F1000Res
publishDate 2018
url https://ncbi.nlm.nih.gov/pmc/articles/PMC6039932/
https://ncbi.nlm.nih.gov/pubmed/30026915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.14737.1
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