Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF-α–mediated Apoptosis in Human Lung Endothelial Cells

Nicotinamide phosphoribosyltransferase (NAMPT) exists as both intracellular NAMPT and extracellular NAMPT (eNAMPT) proteins. eNAMPT is secreted into the blood and functions as a cytokine/enzyme (cytozyme) that activates NF-κB signaling via ligation of Toll-like receptor 4 (TLR4), further serving as...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Principais autores: Oita, Radu C., Camp, Sara M., Ma, Wenli, Ceco, Ermelinda, Harbeck, Mark, Singleton, Patrick, Messana, Joe, Sun, Xiaoguang, Wang, Ting, Garcia, Joe G. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039874/
https://ncbi.nlm.nih.gov/pubmed/29337590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0155OC
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