Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways

OBJECTIVE—: Reverse cholesterol transport (RCT) is a major mechanism by which HDL (high-density lipoprotein) protects against atherosclerosis. Endothelial lipase (EL) reportedly reduces HDL levels, which, in theory, would increase atherosclerosis. However, it remains unclear whether EL affects RCT i...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Takiguchi, Shunichi, Ayaori, Makoto, Yakushiji, Emi, Nishida, Takafumi, Nakaya, Kazuhiro, Sasaki, Makoto, Iizuka, Maki, Uto-Kondo, Harumi, Terao, Yoshio, Yogo, Makiko, Komatsu, Tomohiro, Ogura, Masatsune, Ikewaki, Katsunori
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039415/
https://ncbi.nlm.nih.gov/pubmed/29748333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311056
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