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Unfolding of a ClC chloride transporter retains memory of its evolutionary history

ClC chloride channels and transporters are important for chloride homeostasis in species from bacteria to human. Mutations in ClC proteins cause genetically inherited diseases, some of which are likely to have folding defects. The ClC proteins present a challenging and unusual biological folding pro...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Min, Duyoung, Jefferson, Robert E., Qi, Yifei, Wang, Jing Yang, Arbing, Mark A., Im, Wonpil, Bowie, James U.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038805/
https://ncbi.nlm.nih.gov/pubmed/29581582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0025-4
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