Crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with acyclovir

Escherichia coli purine nucleoside phosphorylase (PNP), which catalyzes the reversible phosphorolysis of purine ribonucleosides, belongs to the family I hexameric PNPs. Owing to their key role in the purine salvage pathway, PNPs are attractive targets for drug design against some pathogens. Acyclovi...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Timofeev, Vladimir I., Zhukhlistova, Nadezhda E., Abramchik, Yuliya A., Muravieva, Tatiana I., Esipov, Roman S., Kuranova, Inna P.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2018
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038453/
https://ncbi.nlm.nih.gov/pubmed/29969103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X18008087
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