Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

BACKGROUND: Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). These PUFA can undergo enzymatic reactions to produce lipid mediators, as well as reaction with oxygen free radica...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Yang, Bo, Li, Runting, Michael Greenlief, C., Fritsche, Kevin L., Gu, Zezong, Cui, Jiankun, Lee, James C., Beversdorf, David Q., Sun, Grace Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038194/
https://ncbi.nlm.nih.gov/pubmed/29986724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1232-3
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