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Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols

[Image: see text] A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward β-amino alcohols under mild and metal-free conditions. In addit...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Saya, Jordy M., Berabez, Rayan, Broersen, Pim, Schuringa, Imme, Kruithof, Art, Orru, Romano V. A., Ruijter, Eelco
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038100/
https://ncbi.nlm.nih.gov/pubmed/29906122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b01561
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