Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance

Preoperative chemotherapy is a promising strategy for the treatment of esophageal squamous cell carcinoma (ESCC). Acquired resistance to chemotherapy is a major obstacle in improving patient prognosis. Cancer-associated fibroblasts (CAFs) are the primary components of the tumor microenvironment and...

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Опубликовано в: :Cell Death Dis
Главные авторы: Che, Yun, Wang, Jingnan, Li, Yuan, Lu, Zhiliang, Huang, Jianbing, Sun, Shouguo, Mao, Shuangshuang, Lei, Yuanyuan, Zang, Ruochuan, Sun, Nan, He, Jie
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037765/
https://ncbi.nlm.nih.gov/pubmed/29988148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0808-2
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