α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis

Metastasis formation requires active energy production and is regulated at multiple levels by mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their extreme adaptability and plasticity and facilitates resistance to common anticancer therapies. In spite the potential rele...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Atlante, Sandra, Visintin, Alessia, Marini, Elisabetta, Savoia, Matteo, Dianzani, Chiara, Giorgis, Marta, Sürün, Duran, Maione, Federica, Schnütgen, Frank, Farsetti, Antonella, Zeiher, Andreas M., Bertinaria, Massimo, Giraudo, Enrico, Spallotta, Francesco, Cencioni, Chiara, Gaetano, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037705/
https://ncbi.nlm.nih.gov/pubmed/29988033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0802-8
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