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Developing a Novel Sulfoxide-containing MS-cleavable Homobifunctional Cysteine Reactive Cross-linker for Studying Protein-Protein Interactions

Cross-linking mass spectrometry (XL-MS) has become an emerging technology for defining protein-protein interactions (PPIs) and elucidating architectures of large protein complexes. Up to now, the most widely used cross-linking reagents target lysines. While such reagents have been successfully appli...

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Detalles Bibliográficos
Publicado en:Anal Chem
Autores principales: Gutierrez, Craig B., Block, Sarah A., Yu, Clinton, Soohoo, Stephanie M., Huszagh, Alexander S., Rychnovsky, Scott D., Huang, Lan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037416/
https://ncbi.nlm.nih.gov/pubmed/29792801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b01287
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