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Splicing heterogeneity: separating signal from noise

Single-cell analyses have revealed a tremendous variety among cells in the abundance and chemical composition of RNA. Much of this heterogeneity is due to alternative splicing by the spliceosome. Little is known about how many of the resulting isoforms are biologically functional or just provide noi...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Wan, Yihan, Larson, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036703/
https://ncbi.nlm.nih.gov/pubmed/29986741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1467-4
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