Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component of vesicular membrane. Here, we report that PIK3C3 deficiency in zebrafish results in intestinal injury and inflammation. In pik3c3 mutants, gut tube forms b...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhao, Shaoyang, Xia, Jianhong, Wu, Xiuhua, Zhang, Leilei, Wang, Pengtao, Wang, Haiyun, Li, Heying, Wang, Xiaoshan, Chen, Yan, Agnetti, Jean, Li, Yinxiong, Pei, Duanqing, Shu, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035235/
https://ncbi.nlm.nih.gov/pubmed/29980668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05105-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados