The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2

Sequencing of primary colorectal tumors has identified a gene fusion in approximately 3% of colorectal cancer patients of the VTI1A and TCF7L2 genes, encoding a VTI1A-TCF4 fusion protein containing a truncated TCF4. As dysregulation of the Wnt signaling pathway is associated with colorectal cancer d...

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Veröffentlicht in:PLoS One
Hauptverfasser: Davidsen, Johanne, Larsen, Sylvester, Coskun, Mehmet, Gögenur, Ismail, Dahlgaard, Katja, Bennett, Eric Paul, Troelsen, Jesper Thorvald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033461/
https://ncbi.nlm.nih.gov/pubmed/29975781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200215
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