Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

BACKGROUND: HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and strong stromal reaction and has a dismal prognosis with the currently available...

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Bibliografske podrobnosti
izdano v:World J Surg Oncol
Main Authors: Leppänen, Joni, Helminen, Olli, Huhta, Heikki, Kauppila, Joonas H., Isohookana, Joel, Haapasaari, Kirsi-Maria, Parkkila, Seppo, Saarnio, Juha, Lehenkari, Petri P., Karttunen, Tuomo J.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033289/
https://ncbi.nlm.nih.gov/pubmed/29973215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12957-018-1432-4
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