Inhibition of CRM1 activity sensitizes endometrial and ovarian cell lines to TRAIL-induced cell death

BACKGROUND: CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynecological tumors in patients. In the present study, we examined if CRM1, a nucle...

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Fabi, François, Adam, Pascal, Vincent, Keven, Demontigny, Françis, Parent, Sophie, Joncas, France-Hélène, Asselin, Eric
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033231/
https://ncbi.nlm.nih.gov/pubmed/29973205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0252-z
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