Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells

Tyrosine kinase receptors are one of the main targets in cancer therapy. They play an essential role in the modulation of growth factor signaling and thereby inducing cell proliferation and growth. Tyrosine kinase inhibitors such as neratinib bind to EGFR and HER2 receptors and exhibit antitumor act...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Aljakouch, Karim, Lechtonen, Tatjana, Yosef, Hesham K., Hammoud, Mohamad K., Alsaidi, Wissam, Kötting, Carsten, Mügge, Carolin, Kourist, Robert, El‐Mashtoly, Samir F., Gerwert, Klaus
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033014/
https://ncbi.nlm.nih.gov/pubmed/29645336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803394
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