RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Sinkevicius, Kerstin W., Morrison, Thomas R., Kulkarni, Praveen, Caffrey Cagliostro, Martha K., Iriah, Sade, Malmberg, Samantha, Sabrick, Julia, Honeycutt, Jennifer A., Askew, Kim L., Trivedi, Malav, Ferris, Craig F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031352/
https://ncbi.nlm.nih.gov/pubmed/29752287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.032631
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