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QSAR-driven Design, Synthesis and Discovery of Potent Chalcone Derivatives with Antitubercular Activity

New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment regimen. In this work, we have continued the efforts to develop chalcone-based anti-TB compounds by using an in silico design and QSAR...

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Dettagli Bibliografici
Pubblicato in:Eur J Med Chem
Autori principali: Gomes, Marcelo N., Braga, Rodolpho C., Grzelak, Edyta M., Neves, Bruno J., Muratov, Eugene, Ma, Rui, Klein, Larry L., Cho, Sanghyun, Oliveira, Guilherme R., Franzblau, Scott G., Andrade, Carolina Horta
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031314/
https://ncbi.nlm.nih.gov/pubmed/28582669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.05.026
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