2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo

2′-O-galloylhyperin, a major compound of Pyrola incarnata Fisch., possesses a variety of biological and pharmacological activities, including anti-oxidative and anti-inflammatory activities. Nevertheless, the underlying molecular mechanisms of 2′-O-GH in microbial infection and sepsis are not clear....

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Peng, Gao, Chang, Guo, Na, Zhang, Sun-Dong, Wang, Wei, Yao, Li-Ping, Zhang, Jing, Efferth, Thomas, Fu, Yu-Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030669/
https://ncbi.nlm.nih.gov/pubmed/29997508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00679
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