Kruppel-Like Factor 4 Positively Regulates Autoimmune Arthritis in Mouse Models and Rheumatoid Arthritis in Patients via Modulating Cell Survival and Inflammation Factors of Fibroblast-Like Synoviocyte

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes mild to severe joint inflammation. During RA pathogenesis, fibroblast-like synoviocytes (FLS) acquire a tumor-like phenotype and mediate cartilage destruction both directly and indirectly by producing proinflammatory cytokines and...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Choi, Seungjin, Lee, Kijun, Jung, Hyerin, Park, Narae, Kang, Jaewoo, Nam, Ki-Hoan, Kim, Eun-Kyeong, Ju, Ji Hyeon, Kang, Kwi Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030377/
https://ncbi.nlm.nih.gov/pubmed/29997611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01339
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