Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites

Tumors frequently exploit homeostatic mechanisms that suppress expression of IL-12, a central mediator of inflammatory and anti-tumor responses. The p40 subunit of the IL-12 heterodimer, encoded by IL12B, is limiting for these functions. Ovarian carcinoma patients frequently produce ascites which ex...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Unger, Annika, Finkernagel, Florian, Hoffmann, Nathalie, Neuhaus, Felix, Joos, Barbara, Nist, Andrea, Stiewe, Thorsten, Visekruna, Alexander, Wagner, Uwe, Reinartz, Silke, Müller-Brüsselbach, Sabine, Müller, Rolf, Adhikary, Till
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030372/
https://ncbi.nlm.nih.gov/pubmed/29997615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01425
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