Phospholipase D1 regulation of TNF-alpha protects against responses to LPS

Sepsis is a systemic inflammatory disorder with organ dysfunction and represents the leading cause of mortality in non-coronary intensive care units. A key player in septic shock is Tumor Necrosis Factor-alpha (TNF-α). Phospholipase (PL)D1 is involved in the regulation of TNF-α upon ischemia/reperfu...

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Publicat a:Sci Rep
Autors principals: Urbahn, Marc-Andre, Kaup, Sonja Charlotte, Reusswig, Friedrich, Krüger, Irena, Spelleken, Martina, Jurk, Kerstin, Klier, Meike, Lang, Philipp A., Elvers, Margitta
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030188/
https://ncbi.nlm.nih.gov/pubmed/29968773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28331-y
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