Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus

Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction of cytoplasmic AURKA is associated with mitochond...

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Vydáno v:Open Biol
Hlavní autoři: Grant, Rhys, Abdelbaki, Ahmed, Bertoldi, Alessia, Gavilan, Maria P., Mansfeld, Jörg, Glover, David M., Lindon, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030116/
https://ncbi.nlm.nih.gov/pubmed/29899121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170272
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