Loss of protein phosphatase 6 in mouse keratinocytes enhances K‐ras (G12D)‐driven tumor promotion

Here, we address the function of protein phosphatase 6 (PP6) loss on K‐ras‐initiated tumorigenesis in keratinocytes. To do so, we developed tamoxifen‐inducible double mutant (K‐ras (G12D)‐expressing and Ppp6c‐deficient) mice in which K‐ras (G12D) expression is driven by the cytokeratin 14 (K14) prom...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Sci
Auteurs principaux: Kurosawa, Koreyuki, Inoue, Yui, Kakugawa, Yoichiro, Yamashita, Yoji, Kanazawa, Kosuke, Kishimoto, Kazuhiro, Nomura, Miyuki, Momoi, Yuki, Sato, Ikuro, Chiba, Natsuko, Suzuki, Mai, Ogoh, Honami, Yamada, Hidekazu, Miura, Koh, Watanabe, Toshio, Tanuma, Nobuhiro, Tachi, Masahiro, Shima, Hiroshi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029815/
https://ncbi.nlm.nih.gov/pubmed/29758119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13638
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