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Protein Flexibility and Synergy of HMG Domains Underlie U-Turn Bending of DNA by TFAM in Solution

Human mitochondrial transcription factor A (TFAM) distorts DNA into a U-turn, as shown by crystallographic studies. The relevance of this U-turn is associated with transcription initiation at the mitochondrial light strand promoter (LSP). However, it has not been yet discerned whether a tight U-turn...

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Dettagli Bibliografici
Pubblicato in:Biophys J
Autori principali: Rubio-Cosials, Anna, Battistini, Federica, Gansen, Alexander, Cuppari, Anna, Bernadó, Pau, Orozco, Modesto, Langowski, Jörg, Tóth, Katalin, Solà, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028807/
https://ncbi.nlm.nih.gov/pubmed/29248151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.3743
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