Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is essential for cytotoxic CD8(+) T cell responses. In mice, dendritic cells (DCs) that arise from monocytes (mo-DCs) during inflammation have a key function in these responses by cross-presenting antigens locally in p...

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Vydáno v:Nat Commun
Hlavní autoři: Tang-Huau, Tsing-Lee, Gueguen, Paul, Goudot, Christel, Durand, Mélanie, Bohec, Mylène, Baulande, Sylvain, Pasquier, Benoit, Amigorena, Sebastian, Segura, Elodie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028641/
https://ncbi.nlm.nih.gov/pubmed/29967419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04985-0
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