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Modeling leaderless transcription and atypical genes results in more accurate gene prediction in prokaryotes

In a conventional view of the prokaryotic genome organization, promoters precede operons and ribosome binding sites (RBSs) with Shine-Dalgarno consensus precede genes. However, recent experimental research suggesting a more diverse view motivated us to develop an algorithm with improved gene-finding...

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Pubblicato in:Genome Res
Autori principali: Lomsadze, Alexandre, Gemayel, Karl, Tang, Shiyuyun, Borodovsky, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028130/
https://ncbi.nlm.nih.gov/pubmed/29773659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.230615.117
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