Urothelial bladder cancer may suppress perforin expression in CD8(+) T cells by an ICAM-1/TGFβ2 mediated pathway

The immune system plays a significant role in urothelial bladder cancer (UBC) progression, with CD8(+) T cells being capable to directly kill tumor cells using perforin and granzymes. However, tumors avoid immune recognition by escape mechanisms. In this study, we aim to demonstrate tumor immune esc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hartana, Ciputra Adijaya, Ahlén Bergman, Emma, Zirakzadeh, A. Ali, Krantz, David, Winerdal, Malin E., Winerdal, Max, Johansson, Markus, Alamdari, Farhood, Jakubczyk, Tomasz, Glise, Hans, Riklund, Katrine, Sherif, Amir, Winqvist, Ola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028111/
https://ncbi.nlm.nih.gov/pubmed/29966014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200079
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