The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients

BACKGROUND: Genetic risk factors, intestinal microbiota and a dysregulated immune system contribute to the pathogenesis of inflammatory bowel disease (IBD). We have previously demonstrated that dysfunction of protein tyrosine phosphatase non-receptor type 2 (PTPN2) and PTPN22 contributes to alterati...

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Vydáno v:PLoS One
Hlavní autoři: Yilmaz, Bahtiyar, Spalinger, Marianne R., Biedermann, Luc, Franc, Yannick, Fournier, Nicolas, Rossel, Jean-Benoit, Juillerat, Pascal, Rogler, Gerhard, Macpherson, Andrew J., Scharl, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028086/
https://ncbi.nlm.nih.gov/pubmed/29965986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199664
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