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Is It Possible to Develop a “Universal” Influenza Virus Vaccine?: Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem

Current influenza vaccines preferentially generate B-cell responses to the variable hemagglutinin (HA) head. Focusing vaccine-induced antibody responses on epitopes in the conserved HA stem may provide better protection against future drifted and pandemic strains. Understanding the basis for the dom...

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Pubblicato in:Cold Spring Harb Perspect Biol
Autori principali: Andrews, Sarah F., Graham, Barney S., Mascola, John R., McDermott, Adrian B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028068/
https://ncbi.nlm.nih.gov/pubmed/28663207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a029413
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