Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-(13)C-Acetates and 1-(13)C-Pyruvates via Side Arm Hydrogenation

[Image: see text] Hyperpolarized forms of 1-(13)C-acetates and 1-(13)C-pyruvates are used as diagnostic contrast agents for molecular imaging of many diseases and disorders. Here, we report the synthetic preparation of 1-(13)C isotopically enriched and pure from solvent acetates and pyruvates deriva...

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Détails bibliographiques
Publié dans:ACS Omega
Auteurs principaux: Chukanov, Nikita V., Salnikov, Oleg G., Shchepin, Roman V., Kovtunov, Kirill V., Koptyug, Igor V., Chekmenev, Eduard Y.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2018
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026840/
https://ncbi.nlm.nih.gov/pubmed/29978146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00983
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