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Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain

Classical swine fever virus (CSFV) is the cause of classical swine fever (CSF). Nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that is a key enzyme initiating viral RNA replication by a de novo mechanism. It is also an attractive target for the development of anti-CSFV dru...

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Publicat a:J Virol
Autors principals: Li, Weiwei, Wu, Baixing, Soca, Wibowo Adian, An, Lei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026734/
https://ncbi.nlm.nih.gov/pubmed/29720518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00324-18
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