STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist

A pathogen encounter induces interferons, which signal via Janus kinases and STAT transcription factors to establish an antiviral state. However, the host and pathogens are situated in a continuous arms race which shapes host evolution toward optimized immune responses and the pathogens toward enhan...

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Veröffentlicht in:J Virol
Hauptverfasser: Le-Trilling, Vu Thuy Khanh, Wohlgemuth, Kerstin, Rückborn, Meike U., Jagnjic, Andreja, Maaßen, Fabienne, Timmer, Lejla, Katschinski, Benjamin, Trilling, Mirko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026732/
https://ncbi.nlm.nih.gov/pubmed/29743368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00296-18
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