Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster

As opposed to syndromic CNVs caused by single genes, extensive phenotypic heterogeneity in variably-expressive CNVs complicates disease gene discovery and functional evaluation. Here, we propose a complex interaction model for pathogenicity of the autism-associated 16p11.2 deletion, where CNV genes...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Iyer, Janani, Singh, Mayanglambam Dhruba, Jensen, Matthew, Patel, Payal, Pizzo, Lucilla, Huber, Emily, Koerselman, Haley, Weiner, Alexis T., Lepanto, Paola, Vadodaria, Komal, Kubina, Alexis, Wang, Qingyu, Talbert, Abigail, Yennawar, Sneha, Badano, Jose, Manak, J. Robert, Rolls, Melissa M., Krishnan, Arjun, Girirajan, Santhosh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026208/
https://ncbi.nlm.nih.gov/pubmed/29959322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04882-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados