Conformation-dependent binding of a Tetrastatin peptide to α(v)β(3) integrin decreases melanoma progression through FAK/PI(3)K/Akt pathway inhibition

Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma ce...

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Udgivet i:Sci Rep
Main Authors: Lambert, Eléonore, Fuselier, Eloïse, Ramont, Laurent, Brassart, Bertrand, Dukic, Sylvain, Oudart, Jean-Baptiste, Dupont-Deshorgue, Aurélie, Sellier, Christèle, Machado, Carine, Dauchez, Manuel, Monboisse, Jean-Claude, Maquart, François-Xavier, Baud, Stéphanie, Brassart-Pasco, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026150/
https://ncbi.nlm.nih.gov/pubmed/29959360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28003-x
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