Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy

BACKGROUND: The excessive amounts of immunosuppressive factors present in a tumor microenvironment (TME) reduce the effectiveness of cancer vaccines. The main objective of our research was to improve the effectiveness of dendritic cell (DC)-based immunotherapy or chemoimmunotherapy composed of cyclo...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Rossowska, Joanna, Anger, Natalia, Szczygieł, Agnieszka, Mierzejewska, Jagoda, Pajtasz-Piasecka, Elżbieta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025815/
https://ncbi.nlm.nih.gov/pubmed/29954431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0799-y
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