Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with HCC. Hypoxia triggers the epithelial-mesenchymal transition (EMT) of cancer cells, which enhances their malignant character and elevates met...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Chen, Xueran, Zhang, Shangrong, Wang, Zhen, Wang, Fengsong, Cao, Xinwang, Wu, Quan, Zhao, Chenggang, Ma, Huihui, Ye, Fang, Wang, Hongzhi, Fang, Zhiyou
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025706/
https://ncbi.nlm.nih.gov/pubmed/29954442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0787-2
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