Crystallographic studies on damaged DNAs IV. N( 4)-methoxycytosine shows a second face for Watson–Crick base-pairing, leading to purine transition mutagenesis

To investigate the mutation mechanism of purine transitions in DNA damaged with methoxyamine, a  DNA dodecamer with the sequence d(CGCAAATTmo(4)CGCG), where mo(4)C is 2′-deoxy-N(4)-methoxycytidine, has been synthesized and the crystal structure determined by X-ray analysis. The duplex structure is s...

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Bibliographic Details
Main Authors: Hossain, M. Tofazzal, Sunami, Tomoko, Tsunoda, Masaru, Hikima, Takaaki, Chatake, Toshiyuki, Ueno, Yoshihito, Matsuda, Akira, Takénaka, Akio
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC60249/
https://ncbi.nlm.nih.gov/pubmed/11574676
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