DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers

DIS3 (defective in sister chromatid joining) is the catalytic subunit of the exosome, a protein complex involved in the 3′–5′ degradation of RNAs. DIS3 is a highly conserved exoribonuclease, also known as Rrp44. Global sequencing studies have identified DIS3 as being mutated in a range of cancers, w...

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Vydáno v:Biochem J
Hlavní autoři: Robinson, Sophie R., Viegas, Sandra C., Matos, Rute G., Domingues, Susana, Bedir, Marisa, Stewart, Helen J.S., Chevassut, Timothy J., Oliver, Antony W., Arraiano, Cecilia M., Newbury, Sarah F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2018
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024818/
https://ncbi.nlm.nih.gov/pubmed/29802118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170962
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