High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2

Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity. MicroRNAs (miRNAs) are short non-coding RNAs that, after maturation, are loaded onto the RISC effector complex that d...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Cappella, Marisa, Perfetti, Alessandra, Cardinali, Beatrice, Garcia-Manteiga, Jose Manuel, Carrara, Matteo, Provenzano, Claudia, Fuschi, Paola, Cardani, Rosanna, Renna, Laura Valentina, Meola, Giovanni, Falcone, Germana, Martelli, Fabio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023919/
https://ncbi.nlm.nih.gov/pubmed/29955039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0769-5
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